TERA for Rotating Equipment Selection

This thesis looks at creating a multidisciplinary simulation tool for rotating plant equipment selection, specifically gas turbines, for the liquefaction of natural gas (LNG). This is a collaborative project between Shell Global Solutions and Cranfield University in the UK. The TERA LNG tool uses a Techno-economic, Environmental and Risk Analysis (TERA) approach in order to satisfy the multidisciplinary nature of the investigation. The benefits of the tool are to act as an aid to selection, operations and maintenance planning and it also acts as a sensitivity tool for assessing the impact of changes in performance, environmental and financial parameters to the overall economic impact of technology selection. The aim is to not only select technology on the basis of techno-economics but also on the basis of risk analysis. The LNG TERA tool is composed of a number of modules starting with the performance simulation which calculates the thermodynamic conditions in the core of the engine. Next, life estimates of the hot gas path components are made using a mixture of parametric and probabilistic lifing models for the turbine first stage blades, coatings, and combustor liner. This allows for a risk analysis to be conducted before maintenance and economics issues are dealt with. In parallel, emissions estimations are made based on empirical correlations. The modelling exemplifies a methodology which is uniquely applied to this application and there are no studies previous to this which look at so many aspects before making conclusions on plant machinery selection. Comparisons have been done between industrial frame engines based on the General Electric Frame 9E (130 MW) and Frame 7EA (87 MW) engines as well as more complex cycles involving aero-derivation and inter-cooling such as the LM 6000 (42 MW) and LMS 100 (100 MW). Work has also been carried out to integrate the tool to Shell based systems in order to utilise the database of information on failure and maintenance of machinery as well as its performance. The results of the integrated TERA show a clear favour for the aero-derivative engines and the main benefit is the fuel saving, though the life of the hot gas path components is deteriorated much faster. The risk results show that the industrial frame engines have a wider variation in expected life compared to aero-derivatives, though the industrial frames have longer component lives. In the context of maintenance and economics, the aero-derivative engines are better suited to LNG applications. The modular change out design of the aero- derivatives also meant that time to repair was lower, thus reducing lost production. Application of the LNG TERA tool was extended to power generation whereby a series of 6 engines were simulated. The changes required to the modelling were minimal and it shows the flexibility of the TERA philosophy. This study was carried out assuming a given ratio of load split between the engines and hence is sensitive to the way an operator demands power of the engine as opposed to LNG application where the operator tries to drive the engine as hard as possible to get the most production out of the train. The study was limited in the modes of failure which were investigated, a major further work would be to extend the methodology to more components and incorporate fatigue failure. Further, the blade creep and probabilistic coating models were very sensitive to changes in their respective control parameters such as coating thickness allowances and firing temperature. The contribution to the project from the MBA is the statistical techniques used to conduct the risk analysis and data handling as well as financial management techniques such as the Net Present Value (NPV) methodology for project evaluations

Peer review audit of trauma deaths in a developing country

OBJECTIVES: Peer review of trauma deaths can be used to evaluate the efficacy of trauma systems. The objective of this study was to estimate teh proportion of preventable trauma deaths and the factors contributing to poor outcome using peer review in a tertiary care hospital in a developing country. METHODS: All trauma deaths during a 2-year period (1 January 1998 to 30 December 1998) were identified and registered in a computerized trauma registry, and the probability of survival was calculated for all patients. Summary data, including registry information and details of prehospital, emergency room, and definitive care, were provided to all members of the peer review committee 1 week before the committee meeting. The committee then reviewed all cases and classified each death as preventable, potentially preventable, or non-preventable.RESULTS AND CONCLUSION: A total fo 279 patients were registered in the trauma registry during the study period, including 18 trauma deaths. Peer review judged that six were preventable, seven were potentially preventable, and four were non-preventable. One patient was excluded because the record was not available for review. The proportion of preventable and potentially preventable deaths was significantly higher in our study than from developed countries. Of the multiple contributing factors identified, the most important were inadequate prehospital transfer, limited hospital resources, and an absence of integrated and organized trauma care. This study summarizes the challenges faced in trauma care in a developing country

Relationship between incidence of Leucinodes orbonalis (Guenee) and Chlorophyll content in leaves of Brinjal (Solanum melongena L.)

The present study on biochemical basis of resistance against Leucinodes orbonalis infestation was conducted during the year 2011-2012. The results revealed that highest chlorophyll-‘a’- content of 0.497 mg/gfw was recorded in the susceptible genotype SHB-1.The lowest amount of 0.319 and 0.381 mg/gfw was observed in the resistant genotypes Brinjal-85 and Local long respectively, which were significantly different from other evaluated genotypes. The chlorophyll ‘a’content was positively correlated with the brinjal shoot and fruit borer infestation. Thehighest chlorophyll -‘b’- content of 0.442 mg/gfw was recorded at 70 DAT (days after transplanting). The amount of chlorophyll -‘b’- varied significantly among the genotypes at different ages and decreased with the age of crop. The average highest amount of chlorophyll -‘b’- was estimated in the genotype SBH-1 which was significantly at par with hybrid SBH-2. The lowest chlorophyll -‘b’- content was recorded at 40 DAT in the genotype Brinjal-85 followed by Local Long. The lowest amount of total chlorophyll was estimated in the resistant variety as compared to susceptible therefore exhibiting lowest level of infestation

Molecular epidemiology of hcv among health care workers of khyber pakhtunkhwa

<p>Abstract</p> <p>Background</p> <p>Studies of the molecular epidemiology and risk factors for hepatitis C virus (HCV) in health care workers (HCWs) of Peshawar, Khyber Pakhtunkhwa region are scarce. Lack of awareness about the transmission of HCV and regular blood screening is contributing a great deal towards the spread of hepatitis C. This study is an attempt to investigate the prevalence of HCV and its possible association with both occupational and non-occupational risk factors among the HCWs of Peshawar.</p> <p>Results</p> <p>Blood samples of 824 HCWs, aged between 20-59 years were analysed for anti-HCV antibodies, HCV RNA and HCV genotypes by Immunochromatographic tests and PCR. All relevant information was obtained from the HCWs with the help of a questionnaire. The study revealed that 4.13% of the HCWs were positive for HCV antibodies, while HCV RNA was detected in 2.79% of the individuals. The most predominant HCV genotype was 3a and 2a.</p> <p>Conclusion</p> <p>A program for education about occupational risk factors and regular blood screening must be implemented in all healthcare setups of Khyber Pakhtunkhwa province in order to help reduce the burden of HCV infection.</p

Mindfulness-Based Stress Reduction in Women with Overweight or Obesity: A Randomized Clinical Trial.

OBJECTIVE: To evaluate the feasibility and cardiometabolic effects of mindfulness-based stress reduction (MBSR) in women with overweight or obesity. METHODS: Eighty-six women with BMI ≥ 25 kg/m RESULTS: Compared to health education, the MBSR group demonstrated significantly improved mindfulness at 8 weeks (mean change from baseline, 4.5 vs. -1.0; P = 0.03) and significantly decreased perceived stress at 16 weeks (-3.6 vs. -1.3, P = 0.01). In the MBSR group, there were significant reductions in fasting glucose at 8 weeks (-8.9 mg/dL, P = 0.02) and at 16 weeks (-9.3 mg/dL, P = 0.02) compared to baseline. Fasting glucose did not significantly improve in the health education group. There were no significant changes in blood pressure, weight, or insulin resistance in the MBSR group. CONCLUSIONS: In women with overweight or obesity, MBSR significantly reduces stress and may have beneficial effects on glucose. Future studies demonstrating long-term cardiometabolic benefits of MBSR will be key for establishing MBSR as an effective tool in the management of obesity

Joule-heating Effects In the Amorphous Fe40ni40b20 Alloy

The effects of Joule heating on the amorphous Fe40Ni40B20 alloy are investigated by measuring the time behavior of the electrical resistance of ribbon strips during such a treatment. The structural transformations occurring in subsequent stages of the process are studied by means of x-ray-diffraction, differential-scanning-calorimetry, and magnetic-permeability measurements. A continuous evolution from a fully amorphous to a fully crystalline structure may be followed. The crystallization mechanisms observed in Joule-heated samples differ from the ones occurring under conventional heating conditions. The electrical resistance displays a bump in the course of Joule heating. A quantitative model relating such a bump to the extra heat released to the sample by fast crystallization is proposed and discussed

Promiscuous prediction and conservancy analysis of CTL binding epitopes of HCV 3a viral proteome from Punjab Pakistan: an In Silico Approach

<p>Abstract</p> <p>Background</p> <p>HCV is a positive sense RNA virus affecting approximately 180 million people world wide and about 10 million Pakistani populations. HCV genotype 3a is the major cause of infection in Pakistani population. One of the major problems of HCV infection especially in the developing countries that limits the limits the antiviral therapy is the long term treatment, high dosage and side effects. Studies of antigenic epitopes of viral sequences of a specific origin can provide an effective way to overcome the mutation rate and to determine the promiscuous binders to be used for epitope based subunit vaccine design. An <it>in silico </it>approach was applied for the analysis of entire HCV proteome of Pakistani origin, aimed to identify the viral epitopes and their conservancy in HCV genotypes 1, 2 and 3 of diverse origin.</p> <p>Results</p> <p>Immunoinformatic tools were applied for the predictive analysis of HCV 3a antigenic epitopes of Pakistani origin. All the predicted epitopes were then subjected for their conservancy analysis in HCV genotypes 1, 2 and 3 of diverse origin (worldwide). Using freely available web servers, 150 MHC II epitopes were predicted as promiscuous binders against 51 subjected alleles. E2 protein represented the 20% of all the predicted MHC II epitopes. 75.33% of the predicted MHC II epitopes were (77-100%) conserve in genotype 3; 47.33% and 40.66% in genotype 1 and 2 respectively. 69 MHC I epitopes were predicted as promiscuous binders against 47 subjected alleles. NS4b represented 26% of all the MHC I predicted epitopes. Significantly higher epitope conservancy was represented by genotype 3 i.e. 78.26% and 21.05% for genotype 1 and 2.</p> <p>Conclusions</p> <p>The study revealed comprehensive catalogue of potential HCV derived CTL epitopes from viral proteome of Pakistan origin. A considerable number of predicted epitopes were found to be conserved in different HCV genotype. However, the number of conserved epitopes in HCV genotype 3 was significantly higher in contrast to its conservancy in HCV genotype 1 and 2. Despite of the lower conservancy in genotype 1 and 2, all the predicted epitopes have important implications in diagnostics as well as CTL-based rational vaccine design, effective for most population of the world and especially the Pakistani Population.</p

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far